Ofev (Nintedanib) Copay Assistance

Without insurance or copay assistance, generic Ofev can cost over $10,000 per month. The standard dose is 150 mg twice daily. Brand-name Ofev costs more. It runs about $13,000+ per month. Your actual cost depends on your insurance, pharmacy, and assistance program.

Cash prices vary by pharmacy, dose, and region. Most insured patients pay much less. They use Ofev copay cards, nintedanib patient assistance programs, or foundation grants.

At QuickRx, no patient should skip Ofev because of cost. Eligible patients may pay $0 for their Ofev prescription. We help you apply for Ofev copay cards, foundation grants, and nintedanib patient assistance programs. Call (917) 830-2525 to find out what you qualify for.

Ofev copay assistance lowers your out-of-pocket cost for Ofev (nintedanib). It covers three program types: manufacturer copay cards, patient assistance programs, and nonprofit foundation grants.

QuickRx Specialty Pharmacy enrolls you for free. We find the programs you qualify for based on your insurance and finances. Our patient navigators handle all the paperwork. You focus on your treatment.

Each Ofev copay assistance program has its own rules.

• Ofev copay cards serve patients with commercial (private) insurance.
• Nintedanib patient assistance programs serve uninsured patients. They also help patients on Medicare or Medicaid when those plans skip the copay card benefit.

Generic Ofev is also available. This opens up more savings options outside the brand-name copay card program.

QuickRx reviews your situation for free. Call (917) 830-2525 to speak with a patient navigator.

No. QuickRx Specialty Pharmacy enrolls you in copay assistance for free. No fees. No hidden charges. No obligation.

Cost should never block pulmonary fibrosis treatment.

What QuickRx Does For Free:

• Reviews your insurance and finds all available programs
• Compares brand Ofev and generic Ofev savings options
• Completes Ofev copay card and nintedanib patient assistance applications
• Coordinates with your healthcare provider for documentation
• Manages renewals and insurance changes
• Provides ongoing support throughout your Ofev treatment

Yes. Generic Ofev is now available in the United States. It costs less than brand-name Ofev for eligible patients.

Generic Ofev has the same active ingredient as brand Ofev: nintedanib esylate. It comes in the same 100 mg and 150 mg capsules.

Whether you get brand or generic Ofev depends on three things:

• Your insurance formulary
• Your prescriber’s choice
• Your clinical situation

QuickRx patient navigators help you understand your options. We find the best savings programs for brand and generic. Call (917) 830-2525 for a free benefits review.

Medicare patients cannot use manufacturer copay cards. Federal regulations block this.

Good news: other financial help may still be available for Ofev or generic Ofev.

Options for Medicare Patients:

• Nintedanib patient assistance programs: Provide Ofev at reduced or no cost
• Generic Ofev: May fall under a lower cost tier on Medicare Part D
• Pulmonary fibrosis foundation grants: Nonprofits help IPF and ILD patients regardless of insurance
• Medicare Extra Help / Low-Income Subsidy: Helps with specialty drug costs
• State pharmaceutical assistance programs: Varies by state

QuickRx patient navigators review your Medicare coverage and find every option. All for free.

Ofev (nintedanib) is an oral prescription drug. The FDA approved it for three lung conditions in adults.

FDA-Approved Indications for Ofev:

• Idiopathic pulmonary fibrosis (IPF): A chronic lung disease that scars lung tissue. The cause is unknown. Ofev slows the decline of lung function in adults with IPF.
• Progressive pulmonary fibrosis (PPF): Ofev treats chronic progressive fibrosing interstitial lung diseases (ILDs). These ILDs keep getting worse despite treatment. Causes include rheumatoid arthritis, sarcoidosis, and hypersensitivity pneumonitis.
• Systemic sclerosis–associated interstitial lung disease (SSc-ILD): Ofev slows the decline of lung function in patients with ILD from systemic sclerosis (scleroderma).

Ofev does not cure these conditions. It does not reverse existing scar tissue. It works by slowing disease progression and protecting lung function.

You take Ofev (nintedanib) by mouth as a capsule. Take it twice a day, about 12 hours apart.

Ofev Dosing Information:

• Standard dose (no liver impairment): 150 mg every 12 hours with food. Maximum dose: 300 mg per day.
• Reduced dose (mild hepatic impairment, Child-Pugh A): 100 mg every 12 hours with food.
• Moderate to severe hepatic impairment: Ofev is not recommended.
• If you miss a dose, skip it. Take the next dose at the regular time. Do not double up.

Important Administration Notes:

• Swallow capsules whole with liquid. Do not open, chew, or crush. The contents taste bitter and can irritate.
• If you touch the capsule contents, wash your hands right away.
• If you smoke, stop before starting Ofev. Smoking lowers Ofev exposure by about 21%.

Follow your healthcare provider’s dosing instructions.

Diarrhea is the most common side effect of Ofev. Most patients get it. GI side effects are usually mild to moderate. They happen most often in the first 3 months of treatment.

Common Ofev Side Effects (>10%):

• Diarrhea (62% to 76% of patients) — the most frequent side effect
• Nausea (24% to 32%)
• Vomiting (12% to 25%)
• Abdominal pain (15% to 18%)
• Decreased appetite (9% to 11%)
• Weight loss (10% to 12%)
• Increased liver enzymes (13% to 14%)
• Fatigue (10% to 11%)
• Nasopharyngitis (13%)

Many patients keep loperamide (Imodium) on hand for diarrhea. Drink plenty of water. Talk to your healthcare provider about any side effect that worries you.

Yes. Ofev has important warnings. Discuss them with your prescriber before and during treatment.

Important Ofev Warnings:

• Liver toxicity: Serious liver injury can happen. Some cases have been fatal. You will need liver function tests (ALT, AST, bilirubin) before you start Ofev and during the first 3 months. Risk is higher in women, patients under 65 kg, Asian patients, and older patients.
• Diarrhea: Severe diarrhea can cause life-threatening dehydration. Call your doctor right away if it is severe or won’t stop.
• Bleeding: Ofev can raise the risk of serious bleeding. Use with care if you have a bleeding risk or take anticoagulants.
• Arterial thromboembolic events: Heart attacks can happen. Use with care if you have cardiovascular risk factors.
• GI perforation: Rare cases of gastrointestinal perforation can happen. Some have been fatal. Use with care after abdominal surgery, with diverticular disease, or with NSAIDs or corticosteroids.
• Fetal harm: Ofev can cause birth defects or fetal death. Patients who can get pregnant must use highly effective birth control during treatment and for 3 months after the last dose.

This information is for learning only. Review all risks with your prescriber before starting Ofev.

Store Ofev capsules at room temperature.

Ofev Storage Instructions:

• Keep at 68°F to 77°F (20°C to 25°C)
• Brief shifts between 59°F and 86°F (15°C and 30°C) are okay
• Protect from high humidity
• Avoid heat
• Keep in the original container

Questions about storing your Ofev? Call your QuickRx pharmacist at (917) 830-2525.

IPF is a chronic lung disease. Scar tissue (fibrosis) builds up in the lungs. The cause is unknown. “Idiopathic” means the origin is unknown.

As lungs scar, they get stiffer. They cannot move oxygen into the bloodstream as well. Patients feel more breathless over time.

Key Facts About IPF:

• IPF mostly affects adults over 60
• It is more common in men and people with a smoking history
• There is no cure for IPF. Treatment focuses on slowing the disease
• Ofev (nintedanib) and pirfenidone are the two FDA-approved drugs that slow lung function decline in IPF
• Symptoms include shortness of breath, dry cough, fatigue, and a crackling sound in the lungs when you breathe

If you have IPF, work with a pulmonologist who specializes in interstitial lung diseases.

PPF describes a pattern of disease behavior. It is not one specific condition.

In PPF, scarring keeps getting worse despite treatment. This happens in chronic fibrosing interstitial lung diseases (ILDs) no matter the underlying cause.

Unlike IPF, PPF has a known cause. It can show up with:

• Rheumatoid arthritis
• Sarcoidosis
• Hypersensitivity pneumonitis
• Mixed connective tissue disease
• Other inflammatory conditions

When these ILDs keep getting worse and don’t respond to standard treatment, Ofev slows further lung function decline.

A pulmonologist manages PPF. They often work with a rheumatologist or another specialist.

SSc-ILD is a lung complication of systemic sclerosis (scleroderma). Systemic sclerosis is a rare autoimmune disease. It hardens the skin and connective tissues.

When systemic sclerosis hits the lungs, it scars and inflames lung tissue (ILD). This makes breathing harder over time.

SSc-ILD is one of the top causes of illness and death in systemic sclerosis patients. Ofev slows the decline of lung function in SSc-ILD. A rheumatologist and pulmonologist both manage this condition.

Do you have systemic sclerosis and take Ofev? QuickRx patient navigators help you get Ofev copay assistance. Call (917) 830-2525.

Yes. Ofev (nintedanib) has important drug interactions. Tell your healthcare provider and pharmacist about all medications, supplements, and herbal products you take.

Notable Ofev Drug Interactions:

• Anticoagulants (blood thinners): Can raise bleeding risk. Monitor closely.
• Strong CYP3A4 and P-glycoprotein inducers (rifampin, St. John’s wort): Lower Ofev blood levels and reduce its effect. Avoid.
• Strong CYP3A4 and P-glycoprotein inhibitors: Raise Ofev blood levels and worsen side effects. Monitor closely.
• NSAIDs (ibuprofen, naproxen, aspirin): Can raise bleeding risk with Ofev. Ask your doctor first.
• Tobacco (smoking): Lowers Ofev exposure by about 21%. Stop smoking before and during Ofev therapy.
• Letrozole: Can raise Ofev blood levels. Monitor for side effects.

QuickRx pharmacists review all drug interactions when we dispense your Ofev. Call (917) 830-2525 with any questions.

Yes. QuickRx Specialty Pharmacy ships Ofev (nintedanib) and generic Ofev to all 50 states. Free home delivery. Proper shipping to keep your medication safe.

Why Patients Choose QuickRx for Ofev:

• Free Ofev copay assistance enrollment for brand and generic Ofev
• Dedicated patient navigators for IPF, PPF, and SSc-ILD patients
• Prior authorization support and appeals
• URAC- and ACHC-accredited specialty pharmacy
• One-on-one support from enrollment through your treatment

Call (917) 830-2525 or fill out the form on this page to get started.

QuickRx is a URAC- and ACHC-accredited specialty pharmacy. Our patient navigator team gives you hands-on financial support for Ofev.

What Sets QuickRx Apart:

• Patient navigators trained in pulmonary fibrosis, rare lung disease, and autoimmune conditions
• Savings options for brand Ofev AND generic Ofev
• Free Ofev copay card enrollment, nintedanib patient assistance applications, and foundation grants
• Prior authorization and appeals support
• Licensed in all 50 states with free home delivery
• URAC- and ACHC-accredited — the highest standards in specialty pharmacy

No patient with IPF, PPF, or SSc-ILD should go without Ofev due to cost. Fill out the form above or call (917) 830-2525 today.

This page is for education only. It is not medical advice. Ofev (nintedanib) does not cure idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, or systemic sclerosis–associated interstitial lung disease.

Copay assistance program eligibility depends on your insurance, income, and other factors. Programs can change. QuickRx Specialty Pharmacy does not guarantee enrollment in any specific program.

Talk to your healthcare provider about your Ofev treatment plan. If you are pregnant or may become pregnant, talk to your prescriber about the fetal risk of nintedanib before you start therapy.

1. Ofev (nintedanib) [prescribing information]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals Inc; May 2025.
2. Pulmonary Fibrosis Foundation. About pulmonary fibrosis. Available at: pulmonaryfibrosis.org
3. American Lung Association. Idiopathic pulmonary fibrosis. Available at: lung.org
4. Richeldi L, du Bois RM, Raghu G, et al; INPULSIS Trial Investigators. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–2082. PubMed: 24836310
5. Flaherty KR, Wells AU, Cottin V, et al; INBUILD Trial Investigators. Nintedanib in progressive fibrosing interstitial lung diseases. N Engl J Med. 2019;381(18):1718–1727. PubMed: 31566307
6. Distler O, Highland KB, Gahlemann M, et al; SENSCIS Trial Investigators. Nintedanib for systemic sclerosis–associated interstitial lung disease. N Engl J Med. 2019;380(26):2518–2528. PubMed: 31112379
7. US Food and Drug Administration. Ofev prescribing information. Available at: FDA.gov

Written by: Paola Larrabure, Pharma Content Manager at QuickRx Specialty Pharmacy. Paola creates patient-focused content on specialty medications, copay assistance, and rare disease support.

Medically reviewed by: Julia Kravtsova, PharmD, Head Patient Navigator at QuickRx Specialty Pharmacy. Julia is a licensed pharmacist. She reviews all clinical content on this site for accuracy. Her work focuses on patient navigation across oncology, autoimmune disease, rare disease, and pulmonary conditions.

Last Updated: May 12, 2026