Apply for Zortress (everolimus) Copay Assistance Now

Zortress is the brand name for everolimus, an mTOR inhibitor used to prevent organ rejection after a kidney or liver transplant. It is prescribed for adult transplant recipients at low-to-moderate immunologic risk and is taken alongside other immunosuppressant medications.

How Zortress is used in transplant:

Everolimus lowers the activity of the immune system so your body is less likely to attack the transplanted organ. It is given in combination with a calcineurin inhibitor (cyclosporine or tacrolimus) and corticosteroids, with regular blood-level monitoring to keep the dose in the right range. Learn more about post-transplant immunosuppression from the NIH.

Zortress and generic everolimus:

Zortress and generic everolimus contain the same active ingredient at the same transplant strengths. QuickRx dispenses generic everolimus for transplant patients and helps you access copay and financial assistance to keep your medication affordable. Call (917) 830-2525 to learn more.

Yes. QuickRx dispenses generic everolimus for transplant patients and coordinates the financial-assistance programs that lower your out-of-pocket medication costs. Generic everolimus contains the identical active ingredient as brand-name Zortress and meets the same FDA standards for safety and effectiveness.

What QuickRx provides:

• Generic everolimus dispensing: Filled in the transplant strengths your doctor prescribes
• Foundation grant coordination: Applications to independent foundations that help cover medication costs
• Patient assistance programs: Support for Medicare, Medicaid, and uninsured patients
• Insurance and prior authorization support: We handle benefit verification and paperwork
• Nationwide home delivery: Convenient shipping directly to your door

QuickRx does not issue manufacturer copay cards; we facilitate enrollment in programs funded by manufacturers or independent foundations. Learn more about generic drugs from the FDA.

Call (917) 830-2525 to get started with QuickRx.

Generic everolimus for transplant is far less expensive than brand-name Zortress, though it is still a specialty medication. Published cash-price references for generic everolimus transplant-dose tablets run from a few hundred dollars to roughly $1,700 for a 60-tablet supply as of 2026, depending on strength and pharmacy. Brand-name Zortress typically costs considerably more.

Approximate generic everolimus cash prices (60 tablets, 2026):

• 0.5 mg: around $635
• 0.75 mg: around $1,268
• 1 mg: around $1,688

How QuickRx helps lower your everolimus cost:

• Foundation grants: Independent foundations may help cover out-of-pocket costs; eligible patients may pay $0
• Patient assistance programs: Options for Medicare, Medicaid, and uninsured patients
• Insurance coordination: We verify benefits and handle prior authorizations

QuickRx provides all financial-assistance services completely free of charge. Call (917) 830-2525 to find out how much you could save on everolimus.

Pricing shown is an approximate cash-price range compiled from publicly available drug-price references as of 2026 and is provided for general educational purposes only. Actual costs vary by dose, pharmacy, insurance, and region, and change over time. For prescribing information, see the official FDA Zortress label. This is not a quote or guarantee of price.

Yes, generic everolimus is available in transplant strengths, and QuickRx dispenses it. Generic everolimus contains the same active ingredient as brand-name Zortress and offers significant cost savings.

Generic everolimus transplant strengths:

Generic everolimus for transplant is available in 0.25 mg, 0.5 mg, 0.75 mg, and 1 mg tablets from multiple manufacturers. Your transplant team and pharmacist determine the strength and dosing that is right for you based on your blood-level monitoring.

Generic everolimus vs brand Zortress:

• Same active ingredient: Generic everolimus contains the identical compound as Zortress
• FDA-approved: Generic versions must meet the same safety and efficacy standards
• Lower cost: Generic everolimus typically costs far less than brand Zortress
• Assistance available: QuickRx coordinates copay and foundation assistance for generic everolimus

QuickRx dispenses generic everolimus for transplant patients. Call (917) 830-2525 to discuss your options.

Transplant patients can lower their everolimus costs through foundation grants, patient assistance programs, and insurance coordination, and QuickRx handles all of it at no charge. Even as a generic, everolimus is a specialty medication, so financial assistance can make a meaningful difference.

Ways to reduce your everolimus costs:

• Foundation grants: Independent foundations offer grants toward out-of-pocket medication costs for eligible patients
• Patient assistance programs: Programs for uninsured and underinsured patients
• Medicare guidance: Help understanding your Part B and Part D coverage for transplant immunosuppressants
• Insurance advocacy: We verify benefits and manage prior authorizations

How QuickRx helps:

Our patient navigators research every program you may qualify for, complete the applications on your behalf, and monitor for grant openings so you don’t miss a funding window. Eligible patients may pay $0. Call (917) 830-2525 to find out what you qualify for.

Yes. Most transplant patients are on Medicare, and there are several ways to reduce everolimus costs, though Medicare patients cannot use manufacturer copay cards due to federal regulations. QuickRx helps Medicare patients navigate the assistance options available to them.

Assistance options for Medicare patients:

• Foundation grants: Independent charitable foundations provide grants to help cover medication costs for eligible patients
• Medicare Extra Help (LIS): Low-income subsidies that reduce Part D costs. Learn more about Medicare prescription drug assistance.
• State pharmaceutical assistance programs (SPAPs): Some states offer additional prescription assistance

Medicare Part B and transplant immunosuppressants:

Transplant immunosuppressant drugs may be covered under Medicare Part B in certain circumstances following a Medicare-covered transplant, which is different from how most prescription drugs are covered under Part D. Coverage rules are specific and depend on your individual situation. Learn more directly from Medicare.gov on immunosuppressive drug coverage.

QuickRx patient navigators help you understand which coverage applies to you and coordinate assistance accordingly. Call (917) 830-2525 to discuss Medicare options for everolimus.

Several independent charitable foundations offer grants that help transplant patients cover the cost of immunosuppressant medications like everolimus. These foundations are separate from drug manufacturers and open and close funding periodically as money becomes available.

How foundation grants work:

• Diagnosis-based funds: Many foundations offer assistance funds tied to specific conditions, which can include transplant recipients
• Income guidelines: Eligibility is usually based on household income and insurance status
• Limited funding windows: Grant funds can open and close quickly as money is allocated
• Renewable: Some grants can be renewed when funding cycles reopen

How QuickRx helps you access grants:

Because grant funds can open and close quickly, timing matters. QuickRx patient navigators actively monitor foundation openings, complete applications the moment funds become available, and manage renewals so your assistance continues. Call (917) 830-2525 to have QuickRx track grant opportunities for you.

No, QuickRx financial-assistance services are always 100% FREE to patients. We never charge for helping you enroll in patient assistance programs or foundation grants for your everolimus.

What’s included at no cost:

• Program identification: We research all available everolimus assistance options
• Application support: We complete paperwork and submit applications on your behalf
• Insurance verification: We check your benefits and coverage details
• Prior authorization: We coordinate with your doctor for any required approvals
• Ongoing management: We handle renewals and monitor for new savings opportunities
• Refill coordination: We ensure continuous medication supply without gaps

How QuickRx supports patients:

As a specialty pharmacy, QuickRx is reimbursed through normal pharmacy dispensing, so we don’t need to charge patients separately for financial-assistance services. Our goal is to help as many transplant patients as possible access their everolimus affordably.

Ready to get started? Call (917) 830-2525 or complete our online form for free everolimus copay assistance.

Everolimus for transplant is typically taken twice daily by mouth, at doses much lower than those used for cancer. Following your dosing schedule precisely is essential to protect your transplanted organ.

Transplant dosing and administration:

• Twice-daily dosing: Commonly started around 0.75 mg twice daily for kidney transplant or 1 mg twice daily for liver transplant, then adjusted based on blood levels
• Taken with other immunosuppressants: Used together with cyclosporine or tacrolimus and corticosteroids
• Consistent with food: Take the same way (with or without food) each time to keep levels steady
• Same times daily: Take about 12 hours apart at the same times each day
• Swallow whole: Do not crush or chew the tablets

Blood-level monitoring:

Your transplant team checks your everolimus whole-blood trough levels regularly and adjusts your dose to keep it in the target range. Never change your dose on your own. Avoid grapefruit and grapefruit juice, which can raise everolimus levels.

QuickRx pharmacists are available to answer questions about taking everolimus correctly. Call (917) 830-2525.

If you miss a dose of everolimus, contact your transplant team for guidance, and never take two doses at once to make up for a missed one. Keeping your blood levels steady is critical for protecting your transplanted organ, so consistency matters more here than with many other medications.

General guidance for a missed dose:

• Take it soon if you remember quickly: If it is close to your missed time, take it as directed by your transplant team
• Do not double up: Never take two doses together to catch up
• When in doubt, call: Because dosing is tied to your blood levels, your transplant team may give you specific instructions

Tips to avoid missing doses:

• Take your medication at the same two times every day
• Use a pill organizer or medication reminder app
• Set daily alarms on your phone
• Keep your medication in a visible location, away from children

If you frequently miss doses or have questions about your schedule, contact your healthcare provider or call QuickRx at (917) 830-2525.

Everolimus interacts with many medications, which is especially important for transplant patients who often take several drugs at once. Everolimus is processed by the CYP3A4 enzyme and the P-glycoprotein transporter, so drugs that affect these systems can raise or lower your everolimus levels. Always tell your doctor and pharmacist about everything you take.

Medications that may interact with everolimus:

• Strong CYP3A4 inhibitors: Ketoconazole, itraconazole, clarithromycin, and ritonavir can increase everolimus levels
• Strong CYP3A4 inducers: Rifampin, phenytoin, carbamazepine, and St. John’s Wort can reduce everolimus effectiveness
• Calcineurin inhibitors: Cyclosporine raises everolimus levels and requires careful monitoring; your team accounts for this when dosing
• ACE inhibitors: May increase the risk of angioedema when combined with everolimus
• Live vaccines: Should be avoided during treatment because everolimus suppresses the immune system

Foods and supplements to avoid:

• Grapefruit, Seville oranges, and pomelos: Can significantly increase everolimus levels
• St. John’s Wort: Can reduce everolimus effectiveness

Some combinations should be avoided entirely, so a full pharmacist review matters. QuickRx pharmacists review your complete medication list for interactions with everolimus. Call (917) 830-2525 to speak with a pharmacist.

Regular lab monitoring is required while taking everolimus, including everolimus blood-level testing that is central to transplant dosing. Your transplant team schedules these tests to keep your dose in the right range and to watch for side effects.

Common monitoring tests:

• Everolimus trough levels: Whole-blood levels are checked to guide dosing, especially after any dose change
• Complete blood count (CBC): To monitor for low blood cell counts
• Kidney function tests: To monitor your transplanted or native kidney function
• Liver function tests: To check for liver effects
• Blood glucose and lipid panel: Everolimus can raise blood sugar, cholesterol, and triglycerides
• Urine protein: To monitor for proteinuria

When monitoring typically occurs:

• Before starting: Baseline tests establish your normal values
• Frequently early on: More often at first and after any dose adjustment
• Ongoing: Regularly throughout treatment to keep levels in range

Report any signs of infection, breathing problems, or unusual symptoms between visits. Questions about monitoring? Call (917) 830-2525 to speak with a QuickRx pharmacist.

Common side effects of everolimus include mouth sores, increased risk of infection, swelling, high blood sugar, and changes in cholesterol. Because everolimus lowers immune activity to protect your transplant, infection risk is an important consideration. Your transplant team monitors you throughout treatment.

Common everolimus side effects:

• Mouth sores (stomatitis): Your team may recommend an alcohol-free mouthwash to help
• Increased infection risk: Everolimus suppresses the immune system
• Swelling (edema): Including in the legs or ankles
• High blood sugar and high cholesterol: May require monitoring and management
• High blood pressure: May need to be tracked and treated
• Dry mouth: Reported with everolimus; sip water and maintain good oral hygiene

Serious effects requiring immediate attention:

• Non-infectious pneumonitis: Cough, difficulty breathing, or fever
• Serious infections: Fever, chills, or flu-like symptoms
• Kidney problems or blood clots: Report changes in urination or swelling promptly
• Poor wound healing: Especially important around any surgery

Contact your healthcare provider immediately if you experience serious side effects. QuickRx pharmacists are also available at (917) 830-2525.

Everolimus prevents organ rejection by inhibiting the mTOR protein, which reduces the activity of immune cells that would otherwise attack the transplanted organ. This targeted immunosuppression helps your body accept the new organ.

Mechanism of action:

The mTOR (mammalian target of rapamycin) protein helps drive the growth and multiplication of certain immune cells. By binding to a protein called FKBP-12 and inhibiting mTOR, everolimus slows the proliferation of the T-cells and other immune cells involved in rejection. Learn more about kidney transplantation from the NIH.

Why it is combined with other drugs:

Everolimus is used together with a calcineurin inhibitor (cyclosporine or tacrolimus) and corticosteroids. Combining agents that work in different ways provides more complete protection against rejection while allowing each drug to be used at a carefully monitored dose.

Everolimus should not be taken during pregnancy, as it can harm an unborn baby. Women who could become pregnant should use effective contraception during treatment and for a period after stopping, and should discuss family planning with their transplant team.

Important information for women:

• Pregnancy testing: A negative pregnancy test may be required before starting
• Contraception during treatment: Use highly effective birth control while taking everolimus
• After stopping: Continue contraception for at least 8 weeks after the last dose
• Breastfeeding: Do not breastfeed during treatment or for 2 weeks after the last dose

Important information for men:

• Fertility: Everolimus may affect male fertility
• Talk with your team: Discuss contraception if your partner could become pregnant

Family planning is especially important for transplant patients, since managing pregnancy alongside immunosuppression requires specialist coordination. Discuss any pregnancy plans with your transplant team before making changes.

Proper storage of everolimus helps ensure the medication stays effective throughout your treatment. Follow these storage guidelines carefully.

Storage requirements:

• Temperature: Store at room temperature, away from extreme heat
• Light protection: Keep in the original packaging to protect from light
• Moisture: Store in a dry place; avoid humid areas like bathrooms
• Children and pets: Keep out of reach of children and pets

What to avoid:

• Do not freeze: Freezing can damage the medication
• Avoid heat: Do not store near stoves, radiators, or in hot cars
• Keep in the blister pack: Until you are ready to take each dose

Medication disposal:

Ask your pharmacist about proper disposal methods or FDA-approved drug take-back programs. Learn more about safe medication disposal from the FDA.

Questions about storing your everolimus? Call QuickRx at (917) 830-2525.

Zortress and Afinitor both contain everolimus, but they are used for entirely different purposes and at different doses. Understanding the difference helps ensure you get the right assistance for your situation.

Zortress (transplant):

Zortress is the lower-dose everolimus used to prevent organ rejection after a kidney or liver transplant. It is dosed twice daily and adjusted based on blood-level monitoring, and it is taken alongside other immunosuppressants.

Afinitor (cancer and TSC):

Afinitor is the higher-dose everolimus used to treat certain cancers and tuberous sclerosis complex (TSC), typically dosed once daily. If you were prescribed everolimus for cancer or TSC, see our Afinitor (everolimus) copay assistance page. For a side-by-side overview, see our guide on the differences between Afinitor and Zortress.

QuickRx dispenses generic everolimus for transplant patients. Call (917) 830-2525 to discuss copay assistance.

Before starting everolimus, share your complete medical history with your transplant team. This helps ensure everolimus is safe for you and allows your team to monitor for potential complications.

Health conditions to discuss:

• Active infections or recent illness: Everolimus suppresses the immune system
• Liver problems: May require dose adjustments
• Diabetes or blood sugar problems: Everolimus can raise blood sugar
• High cholesterol or triglycerides: Levels may rise during treatment
• Planned surgeries or recent wounds: Everolimus can affect wound healing
• Lung or breathing problems: Risk of non-infectious pneumonitis
• History of hepatitis B: May reactivate during immunosuppression

Pregnancy and fertility:

• Pregnancy status: Testing may be required before starting
• Family planning: Discuss contraception requirements
• Breastfeeding: Must be discontinued during treatment

All medications and supplements:

Bring a complete list of all prescription drugs, over-the-counter medicines, vitamins, and herbal supplements, since many products interact with everolimus. QuickRx pharmacists can help review your list. Call (917) 830-2525.

QuickRx Specialty Pharmacy provides comprehensive support for transplant patients taking everolimus, combining expert pharmacy services with dedicated financial-assistance help. We’re committed to making your treatment as affordable and convenient as possible.

What sets QuickRx apart:

• Free financial assistance: We never charge for enrollment in savings programs
• Dedicated patient navigators: Work with the same team members who know your situation
• Expert pharmacists: Specialized in transplant and specialty medications
• Home delivery: Convenient shipping directly to your door
• Refill coordination: We proactively manage your prescription to prevent gaps in therapy
• Insurance advocacy: We handle prior authorizations and insurance issues on your behalf

Our commitment to patients:

QuickRx is a nationwide specialty pharmacy licensed in all 50 states. We understand that recovering from a transplant is challenging enough without worrying about medication costs. Our team is here to help you access the everolimus you need at the lowest possible cost.

Ready to get started? Call (917) 830-2525 to speak with a patient navigator today.