Adempas (riociguat) lists at $197.42 per tablet, or about $17,768 for a 30-day supply at the usual 3 tablets a day, and generic riociguat lists at $177.68 per tablet, about $15,991 a month, based on Average Wholesale Price from Medi-Span via Lexidrug (October 10, 2026). Those are list prices before insurance. What you actually pay depends on your plan and on the assistance you qualify for, and the right assistance can bring it down.
This guide breaks down what Adempas costs, why the monthly total climbs so fast, how brand and generic compare, and the real ways to pay less.
How Much Does Adempas Cost Without Insurance?
Without insurance, a month of Adempas lists at about $17,768, and a month of generic riociguat at about $15,991.
Every strength of Adempas (0.5 mg, 1 mg, 1.5 mg, 2 mg and 2.5 mg) carries the same per-tablet list price, and so does every strength of generic riociguat, according to Lexidrug. That means a dose increase during titration does not change the price per tablet.
Why Does the Monthly Cost of Adempas Add Up So Fast?
Adempas is taken 3 times a day, so a single month means about 90 tablets.
Adempas is a prescription tablet for adults with pulmonary arterial hypertension (PAH, WHO Group 1) and for chronic thromboembolic pulmonary hypertension (CTEPH, WHO Group 4) that is inoperable or that returns after surgery (FDA prescribing information). Lexidrug lists dosing of 3 times a day, starting at 1 mg (or 0.5 mg in patients at higher risk of low blood pressure) and increasing by 0.5 mg no sooner than every 2 weeks, up to 2.5 mg 3 times a day. At about $197 per tablet, 3 tablets a day is close to $600 a day at list price.
Always take riociguat exactly as prescribed. Do not change your dose or how often you take it without talking to your prescriber.
Is Generic Riociguat Cheaper Than Adempas?
Yes, at list price generic riociguat costs about 10% less than brand Adempas: $19.74 less per tablet, or about $1,777 less for a 30-day supply.
Generic riociguat is available in the United States in the same 5 strengths as the brand (Lexidrug). Whether the generic actually costs you less depends on your plan, because insurers set their own prices and preferred drugs. For more on how the generic compares, read our guide to generic Adempas (riociguat).
What Does Adempas Cost With Insurance?
With insurance, your cost depends on your plan’s deductible, copay or coinsurance, and whether the plan covers the brand, the generic, or both.
Commercial insurance: check your plan’s formulary to see how riociguat is covered and whether prior authorization is needed. Manufacturer copay programs are generally available only to commercially insured patients, and eligibility is set by the sponsor.
Medicare: Adempas and generic riociguat are pharmacy-filled tablets, so they fall under Medicare Part D. Part D has a yearly out-of-pocket limit for covered drugs ($2,100 in 2026), and the Medicare Prescription Payment Plan lets you spread those costs into monthly payments. People with limited income may qualify for Extra Help. Details are on Medicare.gov. Manufacturer copay cards cannot be used with Medicare, Medicaid or other government insurance.
How Can You Lower Your Adempas Cost?
The most common ways to lower your Adempas cost are manufacturer copay programs, patient assistance programs, and independent foundation grants.
- Manufacturer copay programs: for patients with commercial insurance; they can reduce your copay for the brand.
- Patient assistance programs: for patients with limited or no insurance, usually based on household income.
- Foundation grants: independent charities that may help Medicare and other patients with pulmonary hypertension pay their share when a fund is open.
- Ask about the generic: talk to your prescriber and your plan about whether generic riociguat would cost you less.
Sorting through these options takes time, and each one has its own forms and rules. QuickRx patient navigators check which ones fit your insurance and apply on your behalf, free of charge. Eligible patients may pay $0. Learn more about our Adempas copay assistance or call (917) 830-2525.
“Most families see the list price of Adempas and assume they can’t afford it. Once we look at their insurance and every option they qualify for, the number they actually pay can look very different. Our job is to do that legwork for them.
Julia Kravtsova, PharmD
Head Patient Navigator, QuickRx Specialty Pharmacy
Important Safety Information
- Boxed warning: riociguat can harm an unborn baby. Pregnancy must be ruled out before treatment, and patients who can become pregnant should use effective birth control before, during and for 1 month after treatment (Lexidrug; FDA label).
- Do not take riociguat with nitrates or nitric oxide donors, PDE-5 inhibitors (such as sildenafil or tadalafil), nonspecific PDE inhibitors (such as dipyridamole or theophylline) or other sGC stimulators (Lexidrug).
- Riociguat can lower blood pressure and has been linked to serious bleeding. Call your doctor if you feel very dizzy, faint, or notice signs of bleeding (Lexidrug).
- Smoking lowers riociguat levels by about 50% to 60%; tell your care team if you smoke or quit (Lexidrug).
Frequently Asked Questions
How much is Adempas per month?
At list price, a 30-day supply of Adempas (90 tablets at 3 a day) is about $17,768, and generic riociguat is about $15,991, based on AWP from Medi-Span via Lexidrug (October 10, 2026). Your actual cost depends on your insurance and any assistance you qualify for.
Does every strength of Adempas cost the same?
Yes. Lexidrug lists the same per-tablet price for all 5 strengths of Adempas ($197.42) and for all 5 strengths of generic riociguat ($177.68). A dose change during titration does not change the price per tablet.
Does Medicare cover Adempas?
Adempas and generic riociguat are covered under Medicare Part D when they are on your plan’s formulary. Part D has a yearly out-of-pocket limit for covered drugs. Check your plan or visit Medicare.gov for details.
Can I use an Adempas copay card with Medicare?
No. Manufacturer copay cards cannot be used by patients with Medicare, Medicaid or other government insurance. Medicare patients may still qualify for Extra Help or for foundation grants when a fund is open.
Who can help me pay for Adempas?
QuickRx patient navigators check every copay program, patient assistance program and foundation grant you may qualify for and apply on your behalf, free of charge. Eligible patients may pay $0. Call (917) 830-2525 to get started.
Sources and Further Reading
Learn more about Adempas (riociguat) and pulmonary hypertension from these trusted sources:
- FDA: Adempas (riociguat) prescribing information and Medication Guide
- DailyMed (NIH): riociguat drug labels
- FDA: Generic Drug Facts
- MedlinePlus: Pulmonary Hypertension
- National Heart, Lung, and Blood Institute: Pulmonary Hypertension
- Pulmonary Hypertension Association
- Medicare.gov: Part D drug coverage
Clinical Reference: Riociguat (Lexi-Drugs), Lexidrug via UpToDate, Last Updated October 10, 2026. Adempas (riociguat) [prescribing information]. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc; August 2026.
Medical Disclaimer: This article is for general information only and does not replace advice from your doctor or pharmacist. Do not start, stop or change any medication or dose without talking to your prescriber. Prices shown are list prices for reference only. Copay cards, patient assistance programs and foundation grants are offered and controlled by their sponsors, not by QuickRx; eligibility rules are set by each sponsor, not every patient qualifies, and programs may change or close at any time. QuickRx does not issue copay cards; we apply on your behalf.
Written by: Paola Larrabure, Pharma Content Manager
Clinically reviewed by: Julia Kravtsova, PharmD, Head Patient Navigator
Last updated: October 12, 2026
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