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FAQs

What is Xtandi (Enzalutamide)?

Xtandi is an oral medication used to treat prostate cancer. It belongs to a class of drugs called androgen receptor inhibitors, which work by blocking the effect of male hormones (androgens) that can promote the growth of prostate cancer cells.

Learn more about Xtandi here

Who is eligible to take Xtandi?

Xtandi is typically prescribed for men with advanced prostate cancer, including those with:

  • Metastatic castration-resistant prostate cancer (mCRPC)
  • Metastatic castration-sensitive prostate cancer (mCSPC)
  • Non-metastatic castration-resistant prostate cancer (nmCRPC)

Your healthcare provider will determine if Xtandi is suitable based on your medical history and cancer progression.

Is there a generic version of Xtandi available?

Unfortunately, there is no generic on the market for Xtandi. It can also be very hard to find this medication, but we carry it at QuickRx.

How is Xtandi taken?

Xtandi (Enzalutamide) is taken orally as a capsule or tablet, usually once daily, with or without food. It is important to take it exactly as prescribed, at the same time each day. Do not crush or chew the tablets.

What is the difference between Xtandi and other medications used for ADT?

While ultimately your doctor will know best which medication is right for you, if you would like to understand the differences on a few that are commonly prescribed see our blog;
A Patient’s Guide to Androgen Deprivation Therapy (ADT): A Few Medication Options

Is Xtandi covered by insurance?

Xtandi (Enzalutamide) insurance coverage may vary depending on the individual’s insurance plan and the specific circumstances of their treatment. It is recommended to check with your insurance provider to determine your personal coverage details and copay amount.

What are the side effects of Xtandi?
Below is a comprehensive list of possible side effects associated with Xtandi (enzalutamide). While not every patient will experience these effects, it’s essential to be aware of them and report any concerning symptoms to your healthcare provider.

Common Side Effects

These side effects occur in more than 10% of patients taking Xtandi:

  • Fatigue
  • Hot flashes
  • Joint pain (arthralgia)
  • Decreased appetite
  • Diarrhea
  • High blood pressure (hypertension)
  • Dizziness
  • Nausea
  • Back pain
  • Weight loss

Less Common Side Effects

These side effects occur in 1-10% of patients:

  • Headache
  • Swelling in hands, feet, or limbs (edema)
  • Constipation
  • Dry skin
  • Anemia
  • Insomnia
  • Respiratory issues, such as cough
  • Muscle weakness or spasms

Rare but Serious Side Effects

These side effects are uncommon but may require immediate medical attention:

Neurological

  • Seizures (Reported in <1% of patients)
  • Posterior Reversible Encephalopathy Syndrome (PRES): Symptoms include seizures, headache, confusion, or vision changes.
  • Cognitive and memory problems
  • Dizziness leading to falls

Cardiovascular

  • Heart failure
  • Blood clots, including deep vein thrombosis (DVT)
  • Pulmonary embolism (PE): Symptoms include shortness of breath, chest pain, or coughing up blood.

Liver Issues

  • Elevated liver enzymes (transaminases): May indicate liver damage.

Hormonal and Metabolic

  • Gynecomastia (breast swelling or tenderness)
  • Hyperglycemia (high blood sugar)
  • Increased cholesterol levels
  • Low testosterone-related symptoms

Immune System

  • Infections: Such as urinary tract infections (UTIs) or respiratory infections.

Skin and Hair

  • Rash
  • Hair thinning or loss

Psychological

  • Mood changes
  • Anxiety or depression

Allergic Reactions

  • Severe allergic reactions (rare): Symptoms include swelling of the face or throat, difficulty breathing, or rash.
Will I need to monitor aspects of my health while taking Xtandi?

Among other things, your healthcare provider may monitor for the following;

  • Blood pressure changes
  • Liver function (via blood tests)
  • Neurological symptoms
  • Bone Health: Xtandi itself does not cause bone loss, but when used with androgen deprivation therapy (ADT), there is a risk of osteoporosis and fractures.
  • Fertility: Xtandi can affect sperm production and fertility.