Vumerity: A Comprehensive Guide for Patients and Healthcare Providers

Dr And Pt Vumerity Blog

Living with multiple sclerosis (MS) can be challenging, but advancements in treatment options have significantly improved the quality of life for those affected. One such advancement is Vumerity (diroximel fumarate), a relatively new oral medication approved for the treatment of relapsing forms of multiple sclerosis. In this blog, we will delve into what Vumerity is, how it works, its benefits, potential side effects, and what patients and healthcare providers should consider before starting this medication.

What is Vumerity?

Vumerity is an oral disease-modifying therapy (DMT) designed to treat relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It was approved by the U.S. Food and Drug Administration (FDA) in October 2019. Vumerity belongs to the same class of medications as Tecfidera (dimethyl fumarate) and works similarly to help reduce the frequency of MS relapses and slow the progression of disability.

How Does Vumerity Work?

Vumerity is a prodrug, which means it converts into its active form, monomethyl fumarate (MMF), once it is ingested and processed in the body. The exact mechanism by which Vumerity exerts its effects in MS is not fully understood, but it is believed to involve anti-inflammatory and neuroprotective properties. Vumerity activates the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway, which helps protect cells from oxidative stress and inflammation—two key contributors to the damage seen in MS.

Benefits of Vumerity

1. Reduced Relapse Rate

Clinical trials have demonstrated that Vumerity effectively reduces the annualized relapse rate (ARR) in patients with relapsing forms of MS. By lowering the frequency of relapses, patients can experience fewer episodes of worsening symptoms and enjoy a more stable condition.

2. Slowed Disability Progression

Vumerity has been shown to slow the progression of disability associated with MS. This means that patients can maintain their functional abilities and independence for a longer period.

3. Oral Administration

One of the significant advantages of Vumerity is its oral administration. Unlike injectable or infusion therapies, Vumerity is taken as a pill, making it more convenient and less invasive for patients.

4. Improved Gastrointestinal Tolerability

Compared to Tecfidera, Vumerity has an improved gastrointestinal (GI) tolerability profile. This is because Vumerity is metabolized differently, resulting in fewer GI side effects such as diarrhea, nausea, and abdominal pain.

Potential Side Effects

While Vumerity is generally well-tolerated, it can cause side effects in some patients. The most common side effects include:

  • Flushing: A warm, red, or itchy feeling of the skin, often on the face and neck.
  • Gastrointestinal Issues: Although improved compared to Tecfidera, some patients may still experience nausea, diarrhea, or abdominal pain.
  • Liver Enzyme Elevations: Routine blood tests are recommended to monitor liver function.
  • Lymphopenia: A reduction in lymphocyte counts, which can increase the risk of infections.

It is essential for patients to discuss any side effects with their healthcare provider, as some may require adjustments in the treatment regimen or additional supportive care.

Considerations Before Starting Vumerity

1. Medical History

Patients should provide a comprehensive medical history to their healthcare provider, including any past or current liver problems, infections, or allergies. This information helps determine if Vumerity is a suitable option.

2. Pregnancy and Breastfeeding

The safety of Vumerity during pregnancy and breastfeeding has not been fully established. Patients who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider.

3. Blood Tests

Regular blood tests are necessary to monitor liver function and lymphocyte counts. These tests help ensure the safe and effective use of Vumerity and allow for timely intervention if any abnormalities are detected.

4. Medication Interactions

Patients should inform their healthcare provider about all medications they are taking, including prescription drugs, over-the-counter medications, and supplements. Some drugs may interact with Vumerity, affecting its efficacy or increasing the risk of side effects.


Vumerity represents a promising treatment option for individuals with relapsing forms of multiple sclerosis. Its efficacy in reducing relapse rates and slowing disability progression, combined with its oral administration and improved gastrointestinal tolerability, makes it an attractive choice for many patients. However, like all medications, it is essential to weigh the benefits against the potential risks and to work closely with a healthcare provider to ensure the best possible outcomes. If you or someone you know is considering Vumerity as part of their MS treatment plan, consult with a healthcare professional to discuss whether it is the right choice for you.

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