Huntington’s disease (HD) is a neurodegenerative disease that results in the progressive breakdown of the brain’s nerve cells. As HD destroys nerve cells, it deteriorates a person’s physical and mental capabilities. The more the huntingtin or HTT gene sequence repeats in an individual’s genetic code the more present the disorder. Generally, those with Huntington’s disease develop symptoms between 30 and 40 years of age.
There is currently no cure for Huntington’s disease. However, medications can significantly lessen movement and psychiatric disorders caused by HD.
Tetrabenazine is used to decrease the uncontrollable movements (chorea) caused by Huntington’s disease. However, it is not a cure for the disease. Reducing the chorea will help you take part in more of your normal daily activities. This medication is thought to work by decreasing the amount of certain natural substances in the brain (monoamines such as dopamine, serotonin, and norepinephrine), which are involved with nerve and muscle function. Tetrabenazine belongs to a class of drugs called monoamine depletors.
How to use Tetrabenazine
Take this medication by mouth with or without food, usually once a day in the morning when you first start treatment or as directed by your doctor. Your doctor may gradually increase your dose to 2 or 3 times a day over several weeks. A slow increase in your dose will help your doctor find the best dose for you while keeping side effects as low as possible.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
If you stop taking this drug for several days, then start taking it again, you may need to slowly increase your dose until you reach the regular dose you had been taking. Follow your doctor’s directions on how to restart treatment.
Tell your doctor if your uncontrolled movements do not improve or if they worsen