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Rapamune (Sirolimus) is primarily used as an immunosuppressant medication. It is often prescribed to prevent organ rejection in transplant patients and to manage certain autoimmune diseases.

While not everyone experiences side effects, some common ones associated with Rapamune may include:

• Mouth Sores: These can be bothersome but are usually manageable.
• High Blood Pressure: Regular monitoring and management are essential.
• High Cholesterol Levels: Dietary adjustments or medication may be required.

1. Calcineurin Inhibitors (Cyclosporine, Tacrolimus):
   • Rapamune is often used in combination with calcineurin inhibitors in transplant patients. However, the doses of both drugs need careful adjustment to minimize the risk of kidney damage and other side effects.
2. Antifungal Medications (Fluconazole, Voriconazole):
   • Certain antifungal drugs can interact with Rapamune, potentially increasing its levels in the blood. This can lead to an increased risk of side effects.
3. Antibiotics (Clarithromycin):
   • Antibiotics like clarithromycin can affect Rapamune’s metabolism, potentially leading to higher drug levels in the blood.
4. Antiseizure Medications (Phenytoin, Carbamazepine):
   • Some antiseizure drugs can decrease the effectiveness of Rapamune. Close monitoring and dosage adjustments may be necessary.
5. St. John’s Wort:
   • Herbal supplements like St. John’s Wort can also interact with Rapamune, reducing its effectiveness. Patients should inform their healthcare provider if they are using herbal supplements.
6. Grapefruit and Grapefruit Juice:
   • Grapefruit and grapefruit juice can increase Rapamune levels in the blood, potentially leading to side effects. It’s advisable to avoid these while on Rapamune.
7. Immunosuppressant Medications (Azathioprine, Mycophenolate):
   • Combining Rapamune with other immunosuppressant medications may increase the risk of immunosuppression-related side effects.
8. Certain Vaccines:
   • Rapamune can weaken the body’s response to certain vaccines. Patients should discuss vaccination schedules with their healthcare provider.
9. Statins (Cholesterol-Lowering Drugs):
   • Patients taking statins alongside Rapamune should be closely monitored for potential interactions that can affect cholesterol levels.

Rapamune (Sirolimus) plays a crucial role in managing transplant patients and certain medical conditions. However, it’s essential to be aware of potential drug interactions. Patients should always inform their healthcare provider about all medications, supplements, and herbal products they are taking to ensure safe and effective treatment.

Seek emergency medical attention or call the Poison Help line immediately at 1-800-222-1222.