Apply for Cortrophin Gel (Repository Corticotropin) Copay Assistance & Patient Savings

Cortrophin Gel copay assistance refers to financial support programs — such as manufacturer copay cards, patient assistance programs, and nonprofit foundation grants — that help reduce the out-of-pocket cost of Cortrophin Gel (repository corticotropin injection) for eligible patients. QuickRx Specialty Pharmacy provides free enrollment support to help you identify and apply for programs you may qualify for based on your insurance and financial situation. Our patient navigators handle the paperwork so you can focus on your treatment.

Eligibility for Cortrophin Gel copay assistance varies by program. Manufacturer copay card programs are generally available to patients with commercial (private) insurance. Patient assistance programs are typically available to patients who are uninsured, underinsured, or whose government insurance (such as Medicare or Medicaid) does not cover the copay card benefit.

QuickRx evaluates your specific situation to identify the programs you are most likely to qualify for and manages all enrollment at no cost to you. Call (917) 830-2525 to speak with a patient navigator.

No. QuickRx Specialty Pharmacy provides copay assistance enrollment support as a completely free service. There are no fees, no hidden charges, and no obligation. Our patient navigator team assists with your Cortrophin Gel application because we believe cost should never be a barrier to treatment.

What QuickRx Does For Free:

• Reviews your insurance coverage and identifies all available programs
• Completes copay card and patient assistance applications on your behalf
• Coordinates with your healthcare provider for required documentation
• Manages ongoing renewals and insurance changes
• Provides continuous support throughout your treatment

Cortrophin Gel (repository corticotropin injection) and Acthar Gel are the two brand-name ACTH medications currently available in the United States — there is no generic version of either drug. Both contain the same active ingredient, repository corticotropin injection, and share many of the same FDA-approved indications.

Key Differences Between Cortrophin Gel and Acthar Gel:

• Price: Cortrophin Gel carries a significantly lower wholesale acquisition cost than Acthar Gel, making it a more accessible option for patients and insurers seeking cost-effective ACTH therapy
• Manufacturer: Cortrophin Gel is manufactured by ANI Pharmaceuticals; Acthar Gel is manufactured by Mallinckrodt (Keenova)
• Indications: Both share most FDA-approved indications; Acthar Gel is additionally approved for infantile spasms, which Cortrophin Gel is not
• Copay assistance caps: The Cortrophin Gel patient support program offers up to $25,000 per calendar year in copay savings for eligible commercially insured patients; Acthar Gel’s commercial copay program offers up to $15,000 per year
• Formulary coverage: Insurance coverage varies by plan; some plans may prefer one product over the other

QuickRx patient navigators can help you understand which product your insurance covers and identify the best savings options available to you. Call (917) 830-2525 for a free benefits review.

Medicare patients cannot use manufacturer copay cards due to federal regulations. However, other financial assistance options may still be available for Cortrophin Gel.

Options for Medicare Patients:

• Patient assistance programs: May provide Cortrophin Gel at reduced or no cost for qualifying patients
• Nonprofit foundation grants: Condition-specific foundations for MS, lupus, and rheumatic diseases may offer assistance regardless of insurance type
• Medicare Extra Help / Low-Income Subsidy: May help with specialty drug costs for qualifying patients
• State pharmaceutical assistance programs: Varies by state

QuickRx patient navigators can review your specific coverage and identify all available options at no cost to you.

Cortrophin Gel (repository corticotropin injection USP) is a purified, porcine-derived adrenocorticotropic hormone (ACTH) approved by the FDA for multiple conditions. It works by stimulating the adrenal cortex to produce and secrete adrenocortical hormones, including cortisol.

FDA-Approved Indications for Cortrophin Gel:

• Multiple sclerosis: Treatment of acute exacerbations of MS in adults
• Rheumatic disorders: Adjunctive therapy for acute episodes or exacerbations of rheumatoid arthritis (including juvenile rheumatoid arthritis), psoriatic arthritis, ankylosing spondylitis, and acute gouty arthritis
• Collagen diseases: Treatment of exacerbations or maintenance therapy for systemic lupus erythematosus and systemic dermatomyositis (polymyositis)
• Nephrotic syndrome: To induce diuresis or remission of proteinuria in nephrotic syndrome without uremia of idiopathic type or due to lupus erythematosus
• Dermatologic diseases: Treatment of severe erythema multiforme, severe psoriasis, Stevens-Johnson syndrome, atopic dermatitis, and serum sickness
• Ophthalmic diseases: Treatment of severe acute and chronic allergic and inflammatory eye conditions
• Sarcoidosis: Treatment of symptomatic sarcoidosis

Patients should discuss their specific indication and treatment plan with their healthcare provider.

Cortrophin Gel is administered as a subcutaneous (under the skin) or intramuscular (into the muscle) injection — it must never be administered intravenously. It is available in two formulations: a multidose vial and prefilled syringes (approved by the FDA in March 2025).

Administration Notes:

• Multidose vials: Warm the gel to room temperature by rolling between hands for a few minutes before administering; do not microwave or heat on a stove
• Prefilled syringes: Allow to sit at room temperature for 45 minutes after removal from the refrigerator before injecting
• Inject into the abdomen (more than 2 inches from the navel), upper thigh, or upper arm; rotate injection sites
• Avoid injecting into scars, stretch marks, or areas of skin that are irritated, inflamed, or bruised
• The first injection should be performed under the guidance of a healthcare professional; injection training is available through the Cortrophin In Your Corner support program

Always follow your healthcare provider’s specific administration instructions.

Dosing for Cortrophin Gel is highly individualized and depends on the condition being treated, disease severity, and the patient’s response to therapy. The manufacturer’s labeling does not provide specific indication-based dosing for most uses.

General Dosing Information (Adults):

• Usual dosage range: 40 to 80 units every 24 to 72 hours by intramuscular or subcutaneous injection
• Multiple sclerosis acute exacerbations: 80 to 120 units per day for 2 to 3 weeks (used as an alternative when IV corticosteroids cannot be administered or are not tolerated)

Corticotropin therapy should not be stopped abruptly — sudden withdrawal may lead to adrenal insufficiency or recurrent symptoms. Your healthcare provider will guide you on tapering the dose prior to discontinuation. Always follow your prescriber’s specific dosing instructions.

Proper storage of Cortrophin Gel is essential to maintain medication integrity.

Cortrophin Gel Storage Instructions:

• Multidose vials: Store in the refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton, protected from light; may be stored at room temperature 68°F to 77°F (20°C to 25°C) for up to 24 hours
• Prefilled syringes: Store in the original carton in the refrigerator at 36°F to 46°F (2°C to 8°C); may be stored at room temperature up to 77°F (25°C) for up to 24 hours
• Discard 1 mL vials within 6 months and 5 mL vials within 28 days after first use
• Do not freeze, do not shake, and protect from light at all times

If you have questions about storing your Cortrophin Gel, contact your QuickRx pharmacist at (917) 830-2525.

Cortrophin Gel can cause a range of side effects related to its mechanism of stimulating adrenal hormone production. Common side effects include:

• Diarrhea or constipation
• Trouble sleeping (insomnia)
• Increased appetite and weight gain
• Nausea or vomiting
• Stuffy nose
• Acne
• Dizziness or headache
• Fluid retention and swelling
• High blood pressure
• Injection site reactions

This is not a complete list of side effects. Talk to your healthcare provider about any side effects that concern you or do not go away.

Yes. Cortrophin Gel carries important warnings that patients should discuss with their prescriber before and during treatment.

Important Cortrophin Gel Warnings:

• Increased infection risk: Corticotropin therapy may increase susceptibility to infections and can mask the symptoms of active infections, making them harder to diagnose
• Adrenal suppression: Prolonged therapy can suppress the hypothalamic-pituitary-adrenal (HPA) axis; do not stop Cortrophin Gel abruptly — dose must be tapered gradually under medical supervision
• Electrolyte disturbances: May cause sodium retention, potassium wasting, and calcium loss; dietary changes or supplementation may be required
• Elevated blood pressure and fluid retention
• High blood sugar: Use with caution in patients with diabetes mellitus
• Psychiatric disturbances: May cause depression, mood swings, insomnia, or personality changes
• Osteoporosis: Long-term use is associated with bone loss; use with caution in patients at risk
• Cushingoid state: Prolonged use may produce Cushing’s syndrome-like features including weight gain, moon face, and impaired wound healing

This information is for educational purposes only. Patients should review all risks and contraindications thoroughly with their prescribing healthcare provider.

Cortrophin Gel is contraindicated in patients with certain conditions. Patients should inform their healthcare provider of their complete medical history before starting therapy.

Cortrophin Gel Contraindications:

• Hypersensitivity to proteins of porcine (pig) origin
• Scleroderma
• Osteoporosis
• Systemic fungal infections
• Ocular herpes simplex
• Recent surgery
• History of or active peptic ulcer disease
• Congestive heart failure
• Uncontrolled hypertension
• Primary adrenocortical insufficiency or adrenocortical hyperfunction
• Intravenous administration (must only be given subcutaneously or intramuscularly)

Always consult your healthcare provider for a complete review of your medical history and current medications before starting Cortrophin Gel.

Yes. Cortrophin Gel has a number of clinically significant drug interactions due to its systemic corticosteroid-stimulating effects. Always inform your healthcare provider and pharmacist of all medications, supplements, and vaccines you are taking.

Notable Drug Interaction Categories:

• Live vaccines: Should not be administered during corticotropin therapy due to increased risk of vaccine-associated infection; avoid smallpox vaccination entirely during treatment
• NSAIDs (non-steroidal anti-inflammatory drugs): Concurrent use may increase the risk of gastrointestinal ulceration and bleeding
• Antidiabetic agents: Cortrophin Gel may raise blood sugar, reducing the effectiveness of diabetes medications; dose adjustments may be needed
• Diuretics (loop and thiazide): May increase potassium loss when used with corticotropin
• Other immunosuppressants: Combined use may increase immunosuppressive effects and infection risk
• Salicylates (aspirin): Corticotropin may decrease salicylate serum concentrations; withdrawal of corticotropin may result in salicylate toxicity

QuickRx pharmacists perform thorough drug interaction reviews as part of the dispensing process. Call (917) 830-2525 with any questions.

No. There is currently no generic version of Cortrophin Gel (repository corticotropin injection) available in the United States. Cortrophin Gel and Acthar Gel are the only two ACTH products on the market, and both are brand-name specialty medications.

Because no generic alternative exists, copay assistance programs and patient assistance programs are especially important for patients who need repository corticotropin therapy. QuickRx patient navigators can help identify all available financial support options for both Cortrophin Gel and Acthar Gel. Call (917) 830-2525 to get started.

Yes. QuickRx Specialty Pharmacy is licensed to dispense and ship Cortrophin Gel to patients in all 50 states. We provide free home delivery and ensure that temperature-sensitive specialty medications like Cortrophin Gel are shipped under appropriate cold-chain conditions.

Why Patients Choose QuickRx for Cortrophin Gel:

• Authorized Cortrophin Gel specialty pharmacy
• Nationwide shipping to all 50 states
• Free copay assistance enrollment services
• Dedicated patient navigators for MS, lupus, rheumatology, and rare disease patients
• Prior authorization support and appeal assistance
• URAC- and ACHC-accredited specialty pharmacy

Call us at (917) 830-2525 or complete the form on this page to get started.

QuickRx is a URAC- and ACHC-accredited specialty pharmacy with a dedicated patient navigator team and hands-on financial support services for patients on high-cost specialty medications like Cortrophin Gel.

What Sets QuickRx Apart:

• Dedicated patient navigators specializing in MS, lupus, rheumatology, nephrology, and rare disease
• Free copay card enrollment, patient assistance applications, and foundation grant coordination
• Prior authorization management and appeals support
• Licensed in all 50 states with free home delivery
• URAC- and ACHC-accredited — held to the highest standards in specialty pharmacy
• Personal, one-on-one support from enrollment through ongoing treatment

Our goal is to make sure no patient goes without their Cortrophin Gel due to cost. Complete the form above or call us at (917) 830-2525 to get started today.