Have questions on Uptravi (Selexipag)?
QuickRx can help.

Uptravi Copay Assistance comes in the form of various savings programs, which are often referred to as “Uptravi copay cards.” These patient assistance programs can be very difficult for patients to find, enroll, and keep an active status.
Although these programs are free, many people are not aware they exist. That is where QuickRx comes in. We have a highly-skilled team dedicated to helping make prescription copays affordable for all who qualify by facilitating access to these programs.

Here is a link to information on Uptravi Copay Assistance:

Uptravi insurance and/or Medicare coverage may vary depending on factors such as the individual’s insurance plan or the specific circumstances of their treatment. It is recommended to check with your insurance provider to determine your personal coverage details and copay amount. Call us at (917) 830-2525 if you’d like guidance on how to reach your insurance provider. We’re always here to help. 

Common Side Effects

(Reported in ≥10% of patients in clinical studies)

• Headache (most common side effect)

• Jaw pain

• Nausea

• Diarrhea

• Vomiting

• Pain in extremities (arms, legs, hands, feet)

• Myalgia (muscle pain)

• Arthralgia (joint pain)

• Flushing

• Anemia

• Decreased appetite

• Abdominal pain

• Rash

• Insomnia

• Back pain

These side effects tend to be dose-dependent and are often most noticeable when patients start treatment or increase their dose. They may diminish over time as the body adjusts.

Serious Side Effects

1. Hypotension (Low Blood Pressure)

• May cause dizziness or fainting

• Risk increases with other blood pressure–lowering medications

2. Bleeding Events

• Nosebleeds, gum bleeding, or gastrointestinal bleeding

• Use with caution in patients on anticoagulants or antiplatelet therapy

3. Anemia

• Decreased red blood cell count

• Can cause fatigue, pallor, or shortness of breath

• Monitor with routine blood tests

4. Pulmonary Veno-Occlusive Disease (PVOD)

• Rare condition that may worsen with Uptravi

• Signs include worsening respiratory symptoms and pulmonary edema

Laboratory Abnormalities

• Decreased hemoglobin/hematocrit (due to anemia)

• Elevated liver enzymes (rare)

• Electrolyte disturbances (e.g., low potassium in some patients)

• Take with food to reduce gastrointestinal discomfort

• Use over-the-counter remedies (with doctor approval) for headache or diarrhea

• Stay hydrated, especially during dose increases

• Report all side effects to your provider during titration

Titration, in simple terms, means slowly adjusting the dose of a medication over time to find the right amount for your body.

Uptravi requires careful titration—gradually increasing the dose to the individual patient’s maximum tolerated level (up to 1600 mcg twice daily). The titration process is often when side effects are most noticeable. Many patients settle into a “maintenance dose” where side effects become manageable.

Patients should seek medical help if they experience:

• Severe or persistent headache, diarrhea, or jaw pain

• Dizziness, fainting, or signs of low blood pressure

• Sudden shortness of breath or coughing up blood

• Signs of bleeding (e.g., black stools, bloody urine)

• Unusual fatigue, pale skin, or rapid heartbeat